Authors:
Antonio Simone Laganà, Paola Rossetti, Fabrizio Sapia, Benito Chiofalo, Massimo Buscema, Gaetano Valenti, Agnese Maria Chiara Rapisarda, Salvatore Giovanni VitaleAbstract
Polycystic ovary syndrome (PCOS)’s rate is about 6% to10% among the reproductive aged women; it is characterized by menstrual cycle irregularity with oligoanovulation, hyperandrogenism, insulin resistance, and compensatory hyperinsulinemia. Despite the fact that the last two elements are present in a large percentage of PCOS women, they are not mandatory for the diagnosis; in order to explain the pathogenesis in these patients, it was supposed that ovarian theca cells got higher insulin sensitivity probably related to the mechanism of intracellular signalling transduction.